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KMID : 1151820150090060417
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Journal of the Korean Society of Radiology
2015 Volume.9 No. 6 p.417 ~ p.420
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Comparison of Linear-Quadratic Model, Incomplete-Repair Model and Marchese Model in Fractionated Carbon Beam Irradiation
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Choi Eun-Ae
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Abstract
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We obtained Surviving Fraction (SF) after irradiation carbon beam to compare the applicability of the Linear-Quadratic model, Incomplete Repair model, Marchese model. Mathematica software(ver 9.0) used to calcurate parameters and compared result. LQ model could not explain the entire response of fractionated carbon beam irradiation. It becomes necessary to construct models that extend the LQ model of conventional radiotherapy for the carbon beam therapy. By combining both Potentially Lethal Damage Repair (PLDR) and Sublethal Damage Repair (SLDR) a new LQ model can develop that aptly modeled the cellular response to fractionated irradiation.
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KEYWORD
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RBE, Biophysical model, Carbon beam, Clonogenic assay, NB1RGB
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